The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Alpha-1-antitrypsin, domain 1
".
FunFam 26: Serpin 38F, isoform A
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Serine-type endopeptidase inhibitor activity GO:0004867
Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
|
5 | Q8MSJ3 (/ISS) Q8MSJ4 (/ISS) Q9U1I6 (/ISS) Q9VII7 (/ISS) X2JAJ8 (/ISS) |
|
Serine-type endopeptidase inhibitor activity GO:0004867
Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
|
1 | Q7YTY6 (/IDA) |
|
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
|
1 | Q8MSJ4 (/ISS) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Multicellular organism reproduction GO:0032504
The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
|
7 | Q7YTY6 (/HEP) Q8MSJ3 (/HEP) Q8MSJ4 (/HEP) Q9U1I6 (/HEP) Q9VII7 (/HEP) Q9VLZ8 (/HEP) X2JAJ8 (/HEP) |
|
Negative regulation of proteolysis GO:0045861
Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
5 | Q8MSJ3 (/ISS) Q8MSJ4 (/ISS) Q9U1I6 (/ISS) Q9VII7 (/ISS) X2JAJ8 (/ISS) |
|
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
4 | Q8MSJ3 (/IMP) Q9U1I6 (/IMP) Q9VII7 (/IMP) X2JAJ8 (/IMP) |
|
Negative regulation of proteolysis GO:0045861
Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
2 | Q7YTY6 (/ISM) Q9VLZ8 (/ISM) |
|
Negative regulation of antimicrobial peptide production GO:0002785
Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production.
|
1 | Q7YTY6 (/IMP) |
|
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
|
1 | Q7YTY6 (/IDA) |
|
Multicellular organism reproduction GO:0032504
The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
|
1 | Q8MSJ4 (/IEP) |
|
Negative regulation of Toll signaling pathway GO:0045751
Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway.
|
1 | Q7YTY6 (/IDA) |
|
Negative regulation of Toll signaling pathway GO:0045751
Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway.
|
1 | Q7YTY6 (/IGI) |
|
Negative regulation of antifungal innate immune response GO:1905035
Any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response.
|
1 | Q7YTY6 (/IGI) |
|
Negative regulation of antifungal innate immune response GO:1905035
Any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response.
|
1 | Q7YTY6 (/IMP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
7 | Q7YTY6 (/HDA) Q8MSJ3 (/HDA) Q8MSJ4 (/HDA) Q9U1I6 (/HDA) Q9VII7 (/HDA) Q9VLZ8 (/HDA) X2JAJ8 (/HDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
5 | Q8MSJ3 (/ISM) Q8MSJ4 (/ISM) Q9U1I6 (/ISM) Q9VII7 (/ISM) X2JAJ8 (/ISM) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
4 | Q8MSJ3 (/IDA) Q9U1I6 (/IDA) Q9VII7 (/IDA) X2JAJ8 (/IDA) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | Q8MSJ4 (/ISM) |
