CATH Domain 3jymB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.50	Chitinase A; domain 3
	3.10.50.40

Domain Context

CATH Clusters

Superfamily	3.10.50.40
Functional Family	Peptidylprolyl isomerase

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q43207

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q43207

FKB70_WHEAT

Triticum aestivum

70 kDa peptidyl-prolyl isomerase

PDB Structure

PDB	3JYM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain Unger, T., Dym, O., Albeck, S., Jacobovitch, Y., Bernehim, R., Marom, D., Pisanty, O., Breiman, A. J.STRUCT.FUNCT.GENOM.

Network disruptions