CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Leucine carboxyl methyltransferase 1

Enzyme Information

2.1.1.233
[Phosphatase 2A protein]-leucine-carboxy methyltransferase.
based on mapping to UniProt Q04081
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl- L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.
-!- Methylates the C-terminal leucine of phosphatase 2A. -!- A key regulator of protein phosphatase 2A. -!- The methyl ester is hydrolyzed by EC 3.1.1.89. -!- Occurs mainly in the cytoplasm, Golgi region and late endosomes.

UniProtKB Entries (1)

Q04081
LCMT1_YEAST
Saccharomyces cerevisiae S288C
Leucine carboxyl methyltransferase 1

PDB Structure

PDB 2OB2
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A method for the general identification of protein crystals in crystallization experiments using a noncovalent fluorescent dye.
Groves, M.R., Muller, I.B., Kreplin, X., Muller-Dieckmann, J.
Acta Crystallogr.,Sect.D
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