CATH Domain 1guzD02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.110	L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
	3.90.110.10	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family	Malate dehydrogenase

Enzyme Information

1.1.1.37	Malate dehydrogenase. based on mapping to UniProt P0C890 (S)-malate + NAD(+) = oxaloacetate + NADH. -!- Also oxidizes some other 2-hydroxydicarboxylic acids.
1.1.1.37	Malate dehydrogenase. based on mapping to UniProt P80039 (S)-malate + NAD(+) = oxaloacetate + NADH. -!- Also oxidizes some other 2-hydroxydicarboxylic acids.

UniProtKB Entries (2)

P0C890	MDH_PROVB Prosthecochloris vibrioformis Malate dehydrogenase
P80039	MDH_CHLTE Chlorobaculum tepidum TLS Malate dehydrogenase

PDB Structure

PDB	1GUZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases Dalhus, B., Saarinen, M., Sauer, U.H., Eklund, P., Johansson, K., Karlsson, A., Ramaswamy, S., Bjork, A., Synstad, B., Naterstad, K., Sirevag, R., Eklund, H. J.Mol.Biol.