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CATH Superfamily 3.90.1570.40

Pre-mRNA-processing-splicing factor 8 (Prp8), endonuclease domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Pre-mRNA-processing-splicing factor 8 (Prp8), endonuclease domain

The active centre of the spliceosome consists of an intricate network formed by U5, U2 and U6 small nuclear RNAs, and a pre-messenger-RNA substrate. Prp8, a component of the U5 small nuclear ribonucleoprotein particle, crosslinks extensively with this RNA catalytic core. This entry represents the endonuclease domain of Prp8 which is composed of five mixed beta-strands flanked by three alpha-helices. It is most similar structurally to the endonuclease domain of the influenza virus polymerase acidic (PA) subunit, although there is very little sequence conservation PMID:23354046.

GO Diversity

Unique GO annotations
44 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1382 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 3
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Function
Unique EC:
Unique GO: 44
Taxonomy
Unique Species: 1382