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CATH Superfamily 3.40.50.880

Class I glutamine amidotransferase (GATase) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Class I glutamine amidotransferase (GATase) domain

This superfamily represents the class I glutamine amidotransferase domain. Glutamine amidotransferase (GATase) enzymes catalyse the removal of the ammonia group from glutamine and then transfer this group to a substrate to form a new carbon-nitrogen group PMID:4355768. The GATase domain exists either as a separate polypeptidic subunit or as part of a larger polypeptide fused in different ways to a synthase domain. Two classes of GATase domains have been identified PMID:3298209,PMID:6086650: class-I (also known as trpG-type or triad) and class-II (also known as purF-type or Ntn). This entry also include the DJ-1/PfpI protein that contains a catalytic triad or dyad different from the class I GAT triad.

PMID:4355768 PMID:3298209 PMID:6086650 (INTERPRO:IPR029062)

GO Diversity

Unique GO annotations
456 Unique GO terms

EC Diversity

Unique EC annotations
40 Unique EC terms

Species Diversity

Unique species annotations
25064 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 930
Domain clusters (>95% seq id): 101
Domain clusters (>35% seq id): 60
Unique PDBs: 325
Alignments
Structural Clusters (5A): 10
Structural Clusters (9A): 6
FunFam Clusters: 232
Function
Unique EC: 40
Unique GO: 456
Taxonomy
Unique Species: 25064