The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
5'-nuclease
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
466 - - 94.2
2
429 - - 89.2
3
400
3D
5um9A01 - 88.5
4
360 - - 89.1
5
225 - - 49.7
6
202
3D
4mj7B00 - 95.1
7
199 - - 91.8
8
189 - - 20.1
10
181
3D
2wp8J01 - 93.7
9
180 - - 93.9
11
174
3D
3zdeA01 - 58.2
12
135 - - 89.4
13
127 - - 70.8
14
126
3D
2hwxA00 - 91.0
16
118
3D
1a77A01 - 92.3
15
109 - - 68.1
17
105
3D
2hwyB00 - 94.8
18
93 - - 86.5
19
80 - - 83.6
20
79
3D
2lcqA01 - 96.8
21
77 - - 88.8
22
69 - - 56.2
23
68 - - 75.0
24
65 - - 77.9
25
58 - - 82.1
26
53 - - 69.1
27
47 - - 65.4
28
46 - - 55.1
29
44 - - 72.6
30
43 - - 53.0
31
41 - - 77.0
32
40 - - 73.3
33
36 - - 96.2
34
36 - - 11.0
35
33 - - 82.5
36
31 - - 15.9
38
28 - - 78.1
37
AFU_orthologue AFUA_3G13260
28 - - 92.1
39
25 - - 70.9
96
24
3D
5v0eZ01 - 42.4
40
24 - - 73.1
42
22 - - 94.2
41
22 - - 70.5
43
21 - - 5.1
44
21 - - 70.4
46
20 - - 77.5
45
20 - - 89.7
51
AFU_orthologue AFUA_3G13260
17 - - 88.4
48
17 - - 14.6
49
17 - - 2.4
50
17 - - 15.2
47
17 - - 84.8
53
16 - - 35.4
55
16 - - 19.7
57
16 - - 77.5
52
16 - - 2.4
56
16 - - 85.2
54
16 - - 57.9
58
15 - - 13.3
106
15
3D
2h1oD00 - 15.8
61
Eurofung
14 - - 76.5
59
14 - - 8.7
60
14 - - 0.0
68
13
3D
5sv2A00 - 10.6
66
13 - - 11.8
62
13 - - 28.1
64
13 - - 21.5
67
13 - - 39.9
65
SSE-1
13 - - 33.9
63
13 - - 0.0
71
12 - - 79.5
69
12 - - 8.9
70
12 - - 1.0
76
11 - - 2.0
78
11 - - 0.0
74
11 - - 0.0
80
11 - - 47.2
92
11
3D
3h87B00 - 0.0
77
11 - - 0.0
82
11
3D
3dboB00 - 0.9
79
11 - - 2.1
72
11 - - 0.0
73
11 - - 9.9
75
11 - - 0.0
87
10 - - 8.1
85
10 - - 13.8
89
10 - - 18.5
84
10 - - 1.0
90
10 - - 71.1
83
10 - - 1.0
81
10 - - 0.0
86
10 - - 14.4
88
10 - - 15.8
91
9 - - 0.5
93
9 - - 68.5
107
8
3D
6nklB00 - 5.6
94
8 - - 0.0
95
8 - - 9.4
101
7 - - 8.4
98
7 - - 0.0
102
7 - - 5.1
100
7 - - 45.3
99
7 - - 9.4
103
7 - - 87.3
97
7 - - 37.9
110
6 - - 3.7
112
6 - - 75.3
108
6 - - 0.0
105
6 - - 12.2
111
6 - - 36.9
113
6 - - 36.5
109
6 - - 0.0
114
6 - - 33.1
104
6 - - 13.0
119
5 - - 11.8
116
FHA
5 - - 13.7
115
5 - - 79.6
122
5 - - 79.2
125
5 - - 5.4
117
Mkt1 AFU_orthologue AFUA_5G12250
5 - - 28.4
118
5 - - 6.4
124
5 - - 62.7
120
5 - - 0.0
121
5 - - 13.7
123
5 - - 87.6
127
4 - - 13.5
136
4 - - 1.2
138
4 - - 60.5
137
4 - - 1.5
128
4 - - 0.0
130
4 - - 10.5
140
4 - - 71.8
132
4 - - 8.8
139
4 - - 64.5
129
4 - - 0.0
135
4 - - 12.0
126
4 - - 37.3
131
4 - - 0.5
133
4 - - 8.2
134
4 - - 0.9
153
3 - - 8.5
144
3 - - 4.8
151
3 - - 0.8
142
3 - - 9.4
155
3 - - 11.4
154
3 - - 17.7
147
3 - - 62.4
149
3 - - 5.3
156
3 - - 26.2
145
3 - - 6.4
152
3 - - 0.0
150
3 - - 0.5
143
3 - - 0.0
148
3 - - 75.7
141
3 - - 66.4
146
3 - - 8.0
160
2 - - 6.1
193
2 - - 17.9
180
2 - - 3.8
189
2 - - 0.0
177
2 - - 0.7
191
2 - - 0.0
187
2 - - 5.1
170
2 - - 0.0
182
2 - - 33.7
167
2 - - 0.0
163
2 - - 35.3
175
2 - - 0.0
198
2 - - 24.8
184
2 - - 0.0
181
2 - - 27.1
158
2 - - 0.0
165
2 - - 0.5
186
2 - - 0.0
173
2 - - 0.0
196
2 - - 31.7
194
2 - - 0.0
168
2 - - 4.6
178
2 - - 0.7
171
2 - - 0.0
161
2 - - 0.0
197
2 - - 40.8
176
2 - - 0.0
192
2 - - 3.8
199
2 - - 12.6
159
2 - - 0.0
195
2 - - 0.0
162
2 - - 31.6
174
2 - - 10.1
188
2 - - 10.6
183
2 - - 8.5
169
2 - - 0.0
190
2 - - 0.0
157
2 - - 22.8
172
2 - - 0.0
179
2 - - 4.2
166
2 - - 0.0
185
2 - - 0.0
164
2 - - 13.8
211
1 - - 0.0
236
1 - - 0.0
218
1 - - 0.0
285
1 - - 0.0
234
1 - - 0.0
288
1 - - 0.0
246
1 - - 0.0
221
1 - - 0.0
260
1 - - 0.0
205
1 - - 0.0
272
1 - - 0.0
287
1 - - 0.0
262
1 - - 0.0
212
1 - - 0.0
227
1 - - 0.0
255
1 - - 0.0
264
1 - - 0.0
232
1 - - 0.0
225
1 - - 0.0
207
1 - - 0.0
274
1 - - 0.0
250
1 - - 0.0
278
1 - - 0.0
257
1 - - 0.0
276
1 - - 0.0
259
1 - - 0.0
249
1 - - 0.0
202
1 - - 0.0
240
1 - - 0.0
230
1 - - 0.0
214
1 - - 0.0
229
1 - - 0.0
222
1 - - 0.0
217
1 - - 0.0
239
1 - - 0.0
281
1 - - 0.0
269
1 - - 0.0
284
1 - - 0.0
247
1 - - 0.0
289
1 - - 0.0
209
1 - - 0.0
290
1 - - 0.0
210
1 - - 0.0
252
1 - - 0.0
283
1 - - 0.0
271
1 - - 0.0
219
1 - - 0.0
242
1 - - 0.0
206
1 - - 0.0
220
1 - - 0.0
226
1 - - 0.0
244
1 - - 0.0
237
1 - - 0.0
286
1 - - 0.0
254
1 - - 0.0
235
1 - - 0.0
213
1 - - 0.0
265
1 - - 0.0
200
1 - - 0.0
275
1 - - 0.0
224
1 - - 0.0
251
1 - - 0.0
279
1 - - 0.0
256
1 - - 0.0
263
1 - - 0.0
215
1 - - 0.0
245
1 - - 0.0
267
1 - - 0.0
233
1 - - 0.0
208
1 - - 0.0
291
1 - - 0.0
241
1 - - 0.0
280
1 - - 0.0
273
1 - - 0.0
270
1 - - 0.0
201
1 - - 0.0
266
1 - - 0.0
243
1 - - 0.0
231
1 - - 0.0
203
1 - - 0.0
261
1 - - 0.0
204
1 - - 0.0
228
1 - - 0.0
268
1 - - 0.0
223
1 - - 0.0
282
1 - - 0.0
238
1 - - 0.0
253
1 - - 0.0
216
1 - - 0.0
277
1 - - 0.0
258
1 - - 0.0
248
1 - - 0.0
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