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CATH Superfamily 3.30.450.20

PAS domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
PAS domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: PAS domain

Structural domains comprising this superfamily share the structure of the PAS domain of the sensor region in the cytosolic histidine kinase (HK), PdtaS, from Mycobacterium tuberculosis. The N-terminal region of this protein is comprised of closely linked GAF and PAS domains (Superfamily 3.30.450.20), both are ubiquitous and form dimeric interfaces.

PAS domains are known to bind a variety of substrates including chromophores, heme, flavin nucleotides, dioxin and even fatty acids PMID:22115998.

GO Diversity

Unique GO annotations
870 Unique GO terms

EC Diversity

Unique EC annotations
11 Unique EC terms

Species Diversity

Unique species annotations
22702 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 841
Domain clusters (>95% seq id): 157
Domain clusters (>35% seq id): 106
Unique PDBs: 402
Alignments
Structural Clusters (5A): 13
Structural Clusters (9A): 7
FunFam Clusters: 699
Function
Unique EC: 11
Unique GO: 870
Taxonomy
Unique Species: 22702
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