This superfamily represents the domain of Gnk2, composed of two alpha-helices and a five-stranded beta-sheet, which formed a compact single-domain architecture with an alpha+beta-fold. Ginkbilobin-2 (Gnk2) is an antifungal protein found in the endosperm of Ginkgo seeds, which inhibits the growth of phytopathogenic fungi such as Fusarium oxysporum. the proteins with a Gnk2-homologous domain are regarded as one of the largest protein superfamilies, although the role of the conserved Gnk2-homologous domain remains unclear PMID:19603485,PMID:11402176.

This entry describes the Gnk2 domain containing a C-X8-C-X2-C motif, which accounts for the similarity with the extracellular domain of cysteine-rich receptor-like kinases (CRK) (28-31% identical sequence). The domain has a role in salt stress response and has antifungal activity.

PFAM:PF01657, INTERPRO:IPR002902,DOI:10.1002/prot.22494