View in Gene3D

CATH Superfamily 3.30.420.320

DNA-packaging terminase, C-terminal nuclease domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: DNA-packaging terminase, C-terminal nuclease domain

During viral replication, herpesviruses package their DNA into the procapsid by means of the terminase protein complex. In human cytomegalovirus (herpesvirus 5), the terminase is composed of subunits UL89 and UL56. Proteins homologous to UL89 are known in all herpesviruses, as are the other terminase subunits, thus indicating that the DNA packaging mechanism is highly conserved. The ul89 ORF includes two exons separated by a 3902 bp intron. It encodes a two-domain 674 amino acid protein with N-terminal ATPase and C-terminal nuclease activity. This entry represents the C-terminal domain of the terminase PMID:20805464.

GO Diversity

Unique GO annotations
2 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
132 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 15
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 4
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 2
Taxonomy
Unique Species: 132