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CATH Superfamily 3.30.2320.60

FhaA, phosphopeptide-binding domain (DUF3662)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
FhaA, phosphopeptide-binding domain (DUF3662)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: FhaA, phosphopeptide-binding domain (DUF3662)

This superfamily comprises the N-terminal domain characterised in the FHA domain-containing protein FhaA (previously known as Rv0020c) from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide-specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. Fha is one of the major substrates of Ser/Thr protein kinases (STPK) and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis PMID:22275220.

PFAM:PF12401, INTERPRO:IPR022128,DOI:10.1016/j.str.2011.07.011

GO Diversity

Unique GO annotations
3 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1962 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Function
Unique EC:
Unique GO: 3
Taxonomy
Unique Species: 1962
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