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CATH Superfamily 3.10.450.250

S. aureus uracil DNA glycosylase inhibitor

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
S. aureus uracil DNA glycosylase inhibitor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: S. aureus uracil DNA glycosylase inhibitor

Uracil-DNA glycosylase inhibitors are DNA mimic proteins that prevent the DNA binding sites of UDGs (Uracil DNA glycosylase) from interacting with their DNA substrate PMID:24150946. Domains comprising this superfamily share the structure of Staphylococcus aureus' uracil-DNA glycosylase inhibitor (SAUGI) which acts as a uracil-DNA glycosylase inhibitor that breaks the uracil-removing activity of S. aureus uracil-DNA glycosylase (SAUDG). This way, SAUGI prevents SAUDG from binding to its DNA substrate and performing DNA repair PMID:24150946.

GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
34 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 6
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 4
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO:
Taxonomy
Unique Species: 34