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CATH Superfamily 2.170.300.10

Tie2 ligand-binding domain superfamily

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tie2 ligand-binding domain superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Laminin subunit beta-1
592
3D
 4aqsA02 - 88.6
2
Multiple epidermal growth factor-like domains 10
294 - - 86.5
3
tyrosine-protein kinase receptor Tie-1 isoform X1
275 - - 93.7
4
Laminin subunit beta 1
260
3D
 4aqsA03 - 88.3
5
multiple epidermal growth factor-like domains protein 11
194 - - 61.9
6
Multiple epidermal growth factor-like domains protein 11
154 - - 74.6
7
multiple epidermal growth factor-like domains protein 10
145 - - 84.6
8
Laminin subunit alpha 2
101 - - 89.0
9
Terribly reduced optic lobes, isoform AK
64 - - 53.9
10
Scavenger receptor class F member 2
56 - - 77.4
11
cadherin EGF LAG seven-pass G-type receptor 1
51 - - 85.1
12
Heparan sulfate proteoglycan 2
44 - - 75.3
13
Scavenger receptor class F, member 2
41 - - 75.2
14
Multiple epidermal growth factor-like domains protein 10
40 - - 48.9
15
multiple epidermal growth factor-like domains protein 11 isoform X3
38 - - 26.5
16
Multiple epidermal growth factor-like domains 10
36 - - 40.9
17
Multiple epidermal growth factor-like domains protein 11
31 - - 20.4
18
angiopoietin-1 receptor isoform X2
23 - - 19.9
20
Uncharacterized protein
20 - - 80.6
19
Platelet endothelial aggregation receptor 1
20 - - 33.7
21
Platelet endothelial aggregation receptor 1
19 - - 76.5
22
Uncharacterized protein
17 - - 65.0
23
Platelet endothelial aggregation receptor 1
16 - - 86.0
26
laminin subunit alpha-2 isoform X2
15 - - 70.1
25
Platelet endothelial aggregation receptor 1
15 - - 54.5
24
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
15 - - 33.8
27
Multiple epidermal growth factor-like domains 6
14 - - 81.3
28
Uncharacterized protein
13 - - 71.1
29
Platelet endothelial aggregation receptor 1
12 - - 37.7
30
Multiple epidermal growth factor-like domains protein 6
11 - - 25.9
32
Platelet endothelial aggregation receptor 1
10 - - 71.2
31
Dendrite extension defective protein 1
10 - - 11.4
33
platelet endothelial aggregation receptor 1
9 - - 21.2
35
Uncharacterized protein
8 - - 55.8
36
Uncharacterized protein
8 - - 81.5
34
Multiple epidermal growth factor-like domains protein 10
8 - - 23.0
39
Uncharacterized protein
7 - - 74.6
40
Platelet endothelial aggregation receptor 1
7 - - 10.8
37
Netrin-B, isoform G
7 - - 44.8
41
Tyrosine protein kinase receptor tie-1, putative
7 - - 80.4
38
Multiple epidermal growth factor-like domains protein 6
7 - - 54.4
42
Platelet endothelial aggregation receptor 1
7 - - 82.1
43
Multiple EGF-like-domains 10
6 - - 41.8
44
Multiple epidermal growth factor-like domains protein 6
5 - - 12.7
48
scavenger receptor class F member 1 isoform X4
4 - - 40.8
46
Uncharacterized protein
4 - - 34.6
45
Uncharacterized protein
4 - - 52.8
49
Adhesion G protein-coupled receptor L3
4 - - 63.6
47
Scavenger receptor class F member 1 isoform 1
4 - - 60.3
51
LAMinin related. See also lmb
3 - - 20.4
52
Cell death abnormality protein 1
3 - - 13.6
53
Uncharacterized protein
3 - - 36.1
50
Uncharacterized protein
3 - - 27.1
71
Uncharacterized protein
2 - - 0.0
58
Uncharacterized protein
2 - - 41.4
61
Predicted protein
2 - - 44.8
55
Uncharacterized protein
2 - - 18.6
57
Uncharacterized protein
2 - - 26.3
74
Uncharacterized protein
2 - - 0.0
68
Uncharacterized protein
2 - - 0.0
64
Uncharacterized protein
2 - - 1.8
60
Uncharacterized protein
2 - - 41.0
69
Laminin subunit alpha-1-like Protein
2 - - 0.0
65
Uncharacterized protein
2 - - 0.0
63
netrin-4
2 - - 0.0
75
Uncharacterized protein
2 - - 38.9
76
Uncharacterized protein
2 - - 38.5
66
Uncharacterized protein
2 - - 11.7
59
Uncharacterized protein
2 - - 40.6
62
Uncharacterized protein
2 - - 42.8
77
Platelet endothelial aggregation receptor 1
2 - - 41.5
72
Multiple epidermal growth factor-like domains 6
2 - - 12.2
73
Uncharacterized protein
2 - - 10.9
67
Laminin subunit gamma-1
2 - - 4.0
56
Uncharacterized protein
2 - - 17.7
54
Uncharacterized protein
2 - - 20.2
70
Uncharacterized protein
2 - - 8.7
101
Scavenger receptor class F member 1
1 - - 0.0
96
Predicted protein
1 - - 0.0
78
Uncharacterized protein
1 - - 0.0
85
Uncharacterized protein
1 - - 0.0
89
Uncharacterized protein
1 - - 0.0
91
Uncharacterized protein
1 - - 0.0
80
Uncharacterized protein
1 - - 0.0
92
Uncharacterized protein
1 - - 0.0
94
Uncharacterized protein
1 - - 0.0
82
Uncharacterized protein
1 - - 0.0
99
Uncharacterized protein
1 - - 0.0
90
Uncharacterized protein
1 - - 0.0
95
Uncharacterized protein
1 - - 0.0
81
Uncharacterized protein
1 - - 0.0
86
Cell death abnormality protein 1
1 - - 0.0
98
Uncharacterized protein
1 - - 0.0
87
Uncharacterized protein
1 - - 0.0
102
Uncharacterized protein
1 - - 0.0
84
Uncharacterized protein
1 - - 0.0
100
Scavenger receptor class F, member 1
1 - - 0.0
79
Uncharacterized protein
1 - - 0.0
93
Netrin, putative
1 - - 0.0
103
Uncharacterized protein
1 - - 0.0
97
Uncharacterized protein
1 - - 0.0
83
Uncharacterized protein
1 - - 0.0
88
Uncharacterized protein
1 - - 0.0