The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"MyTH4 domain
".
1.25.40.530
superfamily
Functional Families
Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
Superfamily: MyTH4 domain
Structural domains comprising this superfamily share the structure of the myosin tail homology 4 (MyTH4) domain, a conserved domain in the tail domains of several different unconventional myosins PMID:11401444 and a plant kinesin-like protein PMID:1074599, but has more recently been found in several non-motor proteins PMID:12062040. Myosin-X is one of the best characterized unconventional myosin and, even though the function of MyTH4 is not yet fully understood, there is evidence suggesting that the MyTH4 domain of Myosin-X is involved in microtubule binding and therefore could provide a link between an actin-based motor protein and the microtubule cytoskeleton PMID:15372037.
The MyTH4 domain is found in one or two copies associated with other domains, such as myosin head, kinesin motor, FERM, PH, SH3 and IQ.
GO Diversity
Unique GO annotations
146 Unique GO terms
EC Diversity
Unique EC annotations
0 Unique EC terms
Species Diversity
Unique species annotations
811 Unique species
Sequence/Structure Diversity
Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.
Superfamily Summary
A general summary of information for this superfamily.
| Structures | |
|---|---|
| Domains: | 5 |
| Domain clusters (>95% seq id): | 2 |
| Domain clusters (>35% seq id): | 2 |
| Unique PDBs: | 4 |
| Alignments | |
| Structural Clusters (5A): | 2 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 31 |
| Function | |
| Unique EC: | |
| Unique GO: | 146 |
| Taxonomy | |
| Unique Species: | 811 |