View in Gene3D

CATH Superfamily 1.25.40.340

DhaL domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: DhaL domain

This entry represents the DhaL domain which consists of eight antiparallel alpha-helices arranged in an up-and-down geometry and aligned on a circle. This results in the formation of a helix barrel enclosing a deep pocket. The helices are amphipathic with the hydrophobic side chains directed into the pocket of the barrel and with the polar residues exposed. The nucleotide is bound on the top of the barrel PMID:16647083,PMID:12966101.

The DhaL alpha helix barrel fold appears not only as a C-terminal domain in Dha kinases but also as an N-terminal domain in a family of two-domain proteins with unknown function. One representative example is YfhG of Lactococcus lactis PMID:12966101.

PMID:16647083 PMID:12966101 PMID:12966101

GO Diversity

Unique GO annotations
28 Unique GO terms

EC Diversity

Unique EC annotations
6 Unique EC terms

Species Diversity

Unique species annotations
7804 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 12
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 15
Function
Unique EC: 6
Unique GO: 28
Taxonomy
Unique Species: 7804