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CATH Superfamily 1.20.190.30

CAG pathogenicity island protein, CagZ

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CAG pathogenicity island protein, CagZ
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: CAG pathogenicity island protein, CagZ

This superfamily is made up of 7 alpha helices, and is 179 residues in length.

CagZ is found in Heliobacter pilori, and is important for the translocation of CagA. CagA is a major antigenic virulence factor that disrupts host cell signalling cascades when phosphorylated. As such, CagZ is essential for the formation of H. pilori's type IV secretion system.

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
16 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO: 1
Taxonomy
Unique Species: 16