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CATH Superfamily 1.20.120.1260

CRISPR-Cas system, Cmr2 subunit, D4 domain, six-helix bundle

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CRISPR-Cas system, Cmr2 subunit, D4 domain, six-helix bundle
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: CRISPR-Cas system, Cmr2 subunit, D4 domain, six-helix bundle

Cmr2 is a subunit of CRISPR RNA-Cas protein complex and belongs to the greater Cas10 family of proteins. Its function is the recognition and cleavage of foreign RNA to protect prokaryotes from invading genetic elements. Cmr2 lacking the N-terminal HD (Histidine-Aspartate) hydrolase domain (Cmr2dHD) is fully functional in RNA cleavage as part of the Cmr complex.

The D4 domain adopts a six-helix bundle, which is homologous with structures of diverse functions. The most relevant structural homologue to D4 is Cmr5, another Cmr complex subunit, which suggests it may perform a similar function or they may interact with each other in the Cmr complex.

DOI:10.1016/j.str.2012.01.018,DOI:10.1016/j.febslet.2012.02.036

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
8 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 6
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO: 1
Taxonomy
Unique Species: 8