The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Ribosomal protein L11, C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ribosomal protein L11/L12, C-terminal domain

This superfamily includes the ribosomal protein L11 found in the large (50S) ribosomal subunit, including homologues from other organisms such as bacteria, plant chloroplast, red algal chloroplast, cyanelle and archaeabacterial. The mammalian, plant and yeast homologues are known as L12 (in yeast, YL15).

L11 consists of a 23S rRNA binding C-terminal domain and an N-terminal domain that directly contacts protein synthesis factors. These two domains are joined by a flexible linker that allows inter-domain movement during protein synthesis. This entry represents the C-terminal domain of L11/L12. The domain consists of a three-helical bundle and a short parallel two-stranded beta-ribbon, with an overall alpha3-beta4-alpha4-alpha5-beta5 topology. All five secondary structure elements contribute to a conserved hydrophobic core. The domain is characterised by two extended loops that are disordered in the absence of the RNA but have defined structures in the complex.

L11 is known to bind directly to the 23S rRNA and plays a significant role during initiation, elongation, and termination of protein synthesis. While the C-terminal domain of L11 binds RNA tightly, the N-terminal domain makes only limited contacts with RNA and is proposed to function as a switch that reversibly associates with an adjacent region of RNA. In E. coli, the C-terminal half of L11 has been shown to be in an extended and loosely folded conformation and is likely to be buried within the ribosomal structure.

PFAM:PF00298, INTERPRO:IPR036769,PMID:10338213,PMID:17215866,PMID:18611379,PMID:18406324

GO Diversity

Unique GO annotations
46 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
18241 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 197
Domain clusters (>95% seq id): 11
Domain clusters (>35% seq id): 5
Unique PDBs: 188
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 29
Unique EC:
Unique GO: 46
Unique Species: 18241