CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family (S)-hydroxynitrile lyase

Enzyme Information

4.1.2.47
(S)-hydroxynitrile lyase.
based on mapping to UniProt P52704
(1) An aliphatic (S)-hydroxynitrile = cyanide + an aliphatic aldehyde or ketone. (2) An aromatic (S)-hydroxynitrile = cyanide + an aromatic aldehyde.
-!- Hydroxynitrile lyases catalyzes the the cleavage of hydroxynitriles into cyanide and the corresponding aldehyde or ketone. -!- In nature the liberation of cyanide serves as a defense mechanism against herbivores and microbial attack in plants. -!- In vitro the enzymes from Manihot esculenta and Hevea brasiliensis accept a broad range of aliphatic and aromatic carbonyl compounds as substrates and catalyze the formation of (S)-hydroxynitriles. -!- Formerly EC 4.1.2.37 and EC 4.1.2.39.

UniProtKB Entries (1)

P52704
HNL_HEVBR
Hevea brasiliensis
(S)-hydroxynitrile lyase

PDB Structure

PDB 6YAS
External Links
Method X-RAY DIFFRACTION
Organism Pichia
Primary Citation
Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis.
Zuegg, J., Gruber, K., Gugganig, M., Wagner, U.G., Kratky, C.
Protein Sci.