CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.170 | Beta Complex |
|
2.170.260 | paz domain |
|
2.170.260.10 | paz domain |
Domain Context
CATH Clusters
| Superfamily | paz domain |
| Functional Family | Protein argonaute-2 |
Enzyme Information
| 3.1.26.n2 |
Argonaute-2.
based on mapping to UniProt Q9UKV8
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- The enzyme, isolated from animals, is required for RNA-mediated gene silencing (RNAi).
|
UniProtKB Entries (1)
| Q9UKV8 |
AGO2_HUMAN
Homo sapiens
Protein argonaute-2
|
PDB Structure
| PDB | 6RA4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection.
J.Chem.Inf.Model.
|