CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Lysosomal acid glucosylceramidase

Enzyme Information

2.4.1.-
Hexosyltransferases.
based on mapping to UniProt P04062
3.2.1.104
Steryl-beta-glucosidase.
based on mapping to UniProt P04062
Cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol.
-!- Acts on glucosides of cholesterol and sitosterol, but not on some related sterols such as coprostanol.
3.2.1.45
Glucosylceramidase.
based on mapping to UniProt P04062
D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine.
-!- Also acts on glucosylsphingosine (cf. EC 3.2.1.62).

UniProtKB Entries (1)

P04062
GLCM_HUMAN
Homo sapiens
Lysosomal acid glucosylceramidase

PDB Structure

PDB 6Q6K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish.
Artola, M., Kuo, C.L., Lelieveld, L.T., Rowland, R.J., van der Marel, G.A., Codee, J.D.C., Boot, R.G., Davies, G.J., Aerts, J.M.F.G., Overkleeft, H.S.
J.Am.Chem.Soc.