CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.437 | Apoptosis Regulator Bcl-x |
|
1.10.437.10 | Blc2-like |
Domain Context
CATH Clusters
| Superfamily | Blc2-like |
| Functional Family | Induced myeloid leukemia cell differentiation protein Mcl-1 |
Enzyme Information
UniProtKB Entries (1)
| Q07820 |
MCL1_HUMAN
Homo sapiens
Induced myeloid leukemia cell differentiation protein Mcl-1
|
PDB Structure
| PDB | 6OQC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
CANCER DISCOV
|