CATH Domain 6ny0A00

Superfamily	2.30.30.60
Functional Family

1.5.1.3

Dihydrofolate reductase.

based on mapping to UniProt P00383

5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.

-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

DYR21_ECOLX

Escherichia coli

Dihydrofolate reductase type 2

PDB	6NY0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues. Toulouse, J.L., Yachnin, B.J., Ruediger, E.H., Deon, D., Gagnon, M., Saint-Jacques, K., Ebert, M.C.C.J.C., Forge, D., Bastien, D., Colin, D.Y., Vanden Eynde, J.J., Marinier, A., Berghuis, A.M., Pelletier, J.N. Acs Omega