CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Histone-lysine N-methyltransferase, H3 lysine-79 specific

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8TEK3
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (2)

P62799
H4_XENLA
Xenopus laevis
Histone H4
J3QS39
J3QS39_HUMAN
Homo sapiens
Polyubiquitin-B

PDB Structure

PDB 6NOG
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.
Worden, E.J., Hoffmann, N.A., Hicks, C.W., Wolberger, C.
Cell