CATH Domain 6mo8B00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.920	Histone Acetyltransferase; Chain A
	1.20.920.10	Bromodomain-like

Domain Context

CATH Clusters

Superfamily	Bromodomain-like
Functional Family	Bromodomain-containing protein 4

Enzyme Information

UniProtKB Entries (1)

BRD2_HUMAN

Homo sapiens

Bromodomain-containing protein 2

PDB Structure

PDB	6MO8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor. Sperandio, D., Aktoudianakis, V., Babaoglu, K., Chen, X., Elbel, K., Chin, G., Corkey, B., Du, J., Jiang, B., Kobayashi, T., Mackman, R., Martinez, R., Yang, H., Zablocki, J., Kusam, S., Jordan, K., Webb, H., Bates, J.G., Lad, L., Mish, M., Niedziela-Majka, A., Metobo, S., Sapre, A., Hung, M., Jin, D., Fung, W., Kan, E., Eisenberg, G., Larson, N., Newby, Z.E.R., Lansdon, E., Tay, C., Neve, R.M., Shevick, S.L., Breckenridge, D.G. Bioorg. Med. Chem.