CATH Domain 6jcwH01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Putative ketol-acid reductoisomerase 2

Enzyme Information

1.1.1.86

Ketol-acid reductoisomerase (NADP(+)).

based on mapping to UniProt Q97YJ9

(1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH.

-!- The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382 and EC 1.1.1.383). -!- Formerly EC 1.1.1.89.

UniProtKB Entries (1)

Q97YJ9

ILVC2_SACS2

Saccharolobus solfataricus P2

Putative ketol-acid reductoisomerase 2

PDB Structure

PDB	6JCW
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase. Chen, C.Y., Chang, Y.C., Lin, B.L., Lin, K.F., Huang, C.H., Hsieh, D.L., Ko, T.P., Tsai, M.D. J. Am. Chem. Soc.