CATH Domain 6hw5A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
	3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1

Domain Context

CATH Clusters

Superfamily	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Functional Family	Proteasome subunit alpha type-2

Enzyme Information

3.4.25.1

Proteasome endopeptidase complex.

based on mapping to UniProt P23639

Cleavage of peptide bonds with very broad specificity.

-!- A 20-S protein composed of 28 subunits arranged in four rings of seven. -!- The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity. -!- In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities. -!- The molecule is barrel-shaped, and the active sites are on the inner surfaces. -!- Terminal apertures restrict access of substrates to the active sites. -!- Inhibited by mercurial reagents and some inhibitors of serine endopeptidases. -!- Belongs to peptidase family T1. -!- Formerly EC 3.4.22.21, EC 3.4.24.5 and EC 3.4.99.46.

UniProtKB Entries (1)

P38624

PSB1_YEAST

Saccharomyces cerevisiae S288C

Proteasome subunit beta type-1

PDB Structure

PDB	6HW5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.