CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Putative Cyclin-dependent kinase 1

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P06493
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.
2.7.11.23
[RNA-polymerase]-subunit kinase.
based on mapping to UniProt P06493
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
-!- Appears to be distinct from other protein phosphokinases. -!- Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6. -!- Does not phosphorylate casein, phosvitin or histone. -!- Formerly EC 2.7.1.141.

UniProtKB Entries (2)

P14635
CCNB1_HUMAN
Homo sapiens
G2/mitotic-specific cyclin-B1
K9J4F7
K9J4F7_DESRO
Desmodus rotundus
Cyclin-dependent kinases regulatory subunit

PDB Structure

PDB 6GU3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Wood, D.J., Korolchuk, S., Tatum, N.J., Wang, L.Z., Endicott, J.A., Noble, M.E.M., Martin, M.P.
Cell Chem Biol