CATH Domain 6gclA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Pteridine reductase

Enzyme Information

UniProtKB Entries (1)

O76290_TRYBB

Trypanosoma brucei brucei

Pteridine reductase

PDB Structure

PDB	6GCL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. Linciano, P., Pozzi, C., Iacono, L.D., di Pisa, F., Landi, G., Bonucci, A., Gul, S., Kuzikov, M., Ellinger, B., Witt, G., Santarem, N., Baptista, C., Franco, C., Moraes, C.B., Muller, W., Wittig, U., Luciani, R., Sesenna, A., Quotadamo, A., Ferrari, S., Pohner, I., Cordeiro-da-Silva, A., Mangani, S., Costantino, L., Costi, M.P. J.Med.Chem.