CATH Domain 6fs1B01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.437	Apoptosis Regulator Bcl-x
	1.10.437.10	Blc2-like

Domain Context

CATH Clusters

Superfamily	Blc2-like
Functional Family	Induced myeloid leukemia cell differentiation protein Mcl-1

Enzyme Information

UniProtKB Entries (1)

MCL1_HUMAN

Homo sapiens

Induced myeloid leukemia cell differentiation protein Mcl-1

PDB Structure

PDB	6FS1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Tron, A.E., Belmonte, M.A., Adam, A., Aquila, B.M., Boise, L.H., Chiarparin, E., Cidado, J., Embrey, K.J., Gangl, E., Gibbons, F.D., Gregory, G.P., Hargreaves, D., Hendricks, J.A., Johannes, J.W., Johnstone, R.W., Kazmirski, S.L., Kettle, J.G., Lamb, M.L., Matulis, S.M., Nooka, A.K., Packer, M.J., Peng, B., Rawlins, P.B., Robbins, D.W., Schuller, A.G., Su, N., Yang, W., Ye, Q., Zheng, X., Secrist, J.P., Clark, E.A., Wilson, D.M., Fawell, S.E., Hird, A.W. Nat Commun