CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Epithelial discoidin domain-containing receptor 1

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q08345
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q08345
DDR1_HUMAN
Homo sapiens
Epithelial discoidin domain-containing receptor 1

PDB Structure

PDB 6FIQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.
Richter, H., Satz, A.L., Bedoucha, M., Buettelmann, B., Petersen, A.C., Harmeier, A., Hermosilla, R., Hochstrasser, R., Burger, D., Gsell, B., Gasser, R., Huber, S., Hug, M.N., Kocer, B., Kuhn, B., Ritter, M., Rudolph, M.G., Weibel, F., Molina-David, J., Kim, J.J., Santos, J.V., Stihle, M., Georges, G.J., Bonfil, R.D., Fridman, R., Uhles, S., Moll, S., Faul, C., Fornoni, A., Prunotto, M.
Acs Chem.Biol.