CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family |
Enzyme Information
| 2.1.1.204 |
tRNA (cytosine(38)-C(5))-methyltransferase.
based on mapping to UniProt P40999
S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L- homocysteine + 5-methylcytosine(38) in tRNA.
-!- The eukaryotic enzyme catalyzes methylation of cytosine(38) in the anti-codon loop of tRNA(Asp)(GTC), tRNA(Val)(AAC) and tRNA(Gly)(GCC). -!- Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease. -!- Formerly EC 2.1.1.29.
|
UniProtKB Entries (1)
| P40999 |
PMT1M_SCHPO
Schizosaccharomyces pombe 972h-
TRNA (cytosine(38)-C(5))-methyltransferase
|
PDB Structure
| PDB | 6FDF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine.
Sci Rep
|
