CATH Domain 6f4dA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.10800	NadA-like

Domain Context

CATH Clusters

Superfamily	NadA-like
Functional Family	Quinolinate synthase A

Enzyme Information

2.5.1.72

Quinolinate synthase.

based on mapping to UniProt Q9X1X7

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate.

-!- Quinolinate synthase catalyzes the second step in the de novo biosynthesis of NAD(+) from aspartate in some bacteria, with EC 1.4.3.16 catalyzing the first step and EC 2.4.2.19 the third step. -!- In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme.

UniProtKB Entries (1)

Q9X1X7

NADA_THEMA

Thermotoga maritima MSB8

Quinolinate synthase A

PDB Structure

PDB	6F4D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystallographic Trapping of Reaction Intermediates in Quinolinic Acid Synthesis by NadA. Volbeda, A., Saez Cabodevilla, J., Darnault, C., Gigarel, O., Han, T.H., Renoux, O., Hamelin, O., Ollagnier-de-Choudens, S., Amara, P., Fontecilla-Camps, J.C. ACS Chem. Biol.