CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit alpha

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P25321
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P25321
KAPCA_CRIGR
Cricetulus griseus
CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB 6EH3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and RKp190
Mueller, J.M., Kirschner, R., Heine, A., Geyer, A., Klebe, G.
To be published