CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Cytochrome P450 1A1

Enzyme Information

1.14.14.-
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen.
based on mapping to UniProt P04798
4.2.1.152
Hydroperoxy icosatetraenoate dehydratase.
based on mapping to UniProt P04798
A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H(2)O.
-!- The mammalian enzymes accept a range of hydroperoxy icosatetraenoates (HPETE). -!- The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. -!- The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE). -!- The enzymes also catalyze the reaction of EC 5.4.4.7.

UniProtKB Entries (1)

P04798
CP1A1_HUMAN
Homo sapiens
Cytochrome P450 1A1

PDB Structure

PDB 6DWM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands.
Bart, A.G., Scott, E.E.
J. Biol. Chem.