CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q06187
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q06187
BTK_HUMAN
Homo sapiens
Tyrosine-protein kinase BTK

PDB Structure

PDB 6DI5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit.
Qiu, H., Liu-Bujalski, L., Caldwell, R.D., Follis, A.V., Gardberg, A., Goutopoulos, A., Grenningloh, R., Head, J., Johnson, T., Jones, R., Mochalkin, I., Morandi, F., Neagu, C., Sherer, B.
Bioorg. Med. Chem. Lett.