CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.10860 | Leucine Dehydrogenase, chain A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Leucine Dehydrogenase, chain A, domain 1 |
| Functional Family | Glutamate dehydrogenase 1, mitochondrial |
Enzyme Information
| 1.4.1.3 |
Glutamate dehydrogenase (NAD(P)(+)).
based on mapping to UniProt P00366
L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H.
|
UniProtKB Entries (1)
| P00366 |
DHE3_BOVIN
Bos taurus
Glutamate dehydrogenase 1, mitochondrial
|
PDB Structure
| PDB | 6DHM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis.
FEBS J.
|