CATH Domain 6da4A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P52333

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P52333

JAK3_HUMAN

Homo sapiens

Tyrosine-protein kinase JAK3

PDB Structure

PDB	6DA4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. Casimiro-Garcia, A., Trujillo, J.I., Vajdos, F., Juba, B., Banker, M.E., Aulabaugh, A., Balbo, P., Bauman, J., Chrencik, J., Coe, J.W., Czerwinski, R., Dowty, M., Knafels, J.D., Kwon, S., Leung, L., Liang, S., Robinson, R.P., Telliez, J.B., Unwalla, R., Yang, X., Thorarensen, A. J. Med. Chem.