CATH Classification

Domain Context

CATH Clusters

Superfamily Clavaminate synthase-like
Functional Family

Enzyme Information

1.14.11.44
(R)-dichlorprop dioxygenase (2-oxoglutarate).
based on mapping to UniProt Q8KSC8
(1) (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O(2) = 4-chloro-2-methylphenol + pyruvate + succinate + CO(2). (2) (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O(2) = 2,4- dichlorophenol + pyruvate + succinate + CO(2).
-!- The enzymes from the Gram-negative bacteria Delftia acidovorans MC1 and Sphingomonas herbicidovorans MH are involved in the degradation of the (R)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop.

UniProtKB Entries (1)

Q8KSC8
RDPA_SPHHM
Sphingobium herbicidovorans NBRC 16415
(R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase

PDB Structure

PDB 6D3I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Development of enzymes for robust aryloxyphenoxypropionate and synthetic auxin herbicide tolerance traits in maize and soybean crops.
Larue, C.T., Goley, M., Shi, L., Evdokimov, A.G., Sparks, O.C., Ellis, C., Wollacott, A.M., Rydel, T.J., Halls, C.E., Van Scoyoc, B., Fu, X., Nageotte, J.R., Adio, A.M., Zheng, M., Sturman, E.J., Garvey, G.S., Varagona, M.J.
Pest Manag. Sci.