CATH Classification

Domain Context

CATH Clusters

Superfamily Hemopexin-like domain
Functional Family Matrix metallopeptidase 24

Enzyme Information

3.4.24.80
Membrane-type matrix metalloproteinase-1.
based on mapping to UniProt P50281
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe- 342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
-!- Believed to play an important role in the activation of progelatinase A at cell surfaces. -!- Belongs to peptidase family M10.

UniProtKB Entries (1)

P02647
APOA1_HUMAN
Homo sapiens
Apolipoprotein A-I

PDB Structure

PDB 6CLZ
External Links
Method SOLUTION NMR
Organism
Primary Citation
MT1-MMP Binds Membranes by Opposite Tips of Its beta Propeller to Position It for Pericellular Proteolysis.
Marcink, T.C., Simoncic, J.A., An, B., Knapinska, A.M., Fulcher, Y.G., Akkaladevi, N., Fields, G.B., Van Doren, S.R.
Structure