CATH Domain 6cjhA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Putative map kinase-interacting serine/threonine-protein kinase 1

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q9HBH9

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9HBH9

MKNK2_HUMAN

Homo sapiens

MAP kinase-interacting serine/threonine-protein kinase 2

PDB Structure

PDB	6CJH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. Reich, S.H., Sprengeler, P.A., Chiang, G.G., Appleman, J.R., Chen, J., Clarine, J., Eam, B., Ernst, J.T., Han, Q., Goel, V.K., Han, E.Z.R., Huang, V., Hung, I.N.J., Jemison, A., Jessen, K.A., Molter, J., Murphy, D., Neal, M., Parker, G.S., Shaghafi, M., Sperry, S., Staunton, J., Stumpf, C.R., Thompson, P.A., Tran, C., Webber, S.E., Wegerski, C.J., Zheng, H., Webster, K.R. J. Med. Chem.