CATH Classification

Domain Context

CATH Clusters

Superfamily HUPs
Functional Family Phosphopantetheine adenylyltransferase

Enzyme Information

2.7.7.3
Pantetheine-phosphate adenylyltransferase.
based on mapping to UniProt P0A6I6
ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.
-!- The enzyme from several bacteria (e.g. Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157.

UniProtKB Entries (1)

P0A6I6
COAD_ECOLI
Escherichia coli K-12
Phosphopantetheine adenylyltransferase

PDB Structure

PDB 6CCK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
Moreau, R.J., Skepper, C.K., Appleton, B.A., Blechschmidt, A., Balibar, C.J., Benton, B.M., Drumm, J.E., Feng, B.Y., Geng, M., Li, C., Lindvall, M.K., Lingel, A., Lu, Y., Mamo, M., Mergo, W., Polyakov, V., Smith, T.M., Takeoka, K., Uehara, K., Wang, L., Wei, J.R., Weiss, A.H., Xie, L., Xu, W., Zhang, Q., de Vicente, J.
J. Med. Chem.