CATH Domain 6c62A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1300	Amidase signature (AS) enzymes
	3.90.1300.10	Amidase signature (AS) domain

Domain Context

CATH Clusters

Superfamily	Amidase signature (AS) domain
Functional Family

Enzyme Information

3.5.1.131

1-carboxybiuret hydrolase.

based on mapping to UniProt Q936X3

1-carboxybiuret + H(2)O = urea 1,3-dicarboxylate + NH(3).

-!- The enzyme, characterized from the bacterium Pseudomonas sp ADP, participates in the degradation of cyanuric acid, an intermediate in the degradation of s-triazine herbicides such as atrazine (2-chloro- 4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine). -!- The enzyme is a heterotetramer composed of a catalytic subunit (AtzE) and an accessory subunit (AtzG) that stabilizes the complex.

UniProtKB Entries (1)

Q936X3

ATZE_PSESD

Pseudomonas sp. ADP

1-carboxybiuret hydrolase subunit AtzE

PDB Structure

PDB	6C62
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An unexpected vestigial protein complex reveals the evolutionary origins of ans-triazine catabolic enzyme. Esquirol, L., Peat, T.S., Wilding, M., Liu, J.W., French, N.G., Hartley, C.J., Onagi, H., Nebl, T., Easton, C.J., Newman, J., Scott, C. J. Biol. Chem.