CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1100
Functional Family Cystathionine beta-synthase

Enzyme Information

4.2.1.22
Cystathionine beta-synthase.
based on mapping to UniProt P32582
L-serine + L-homocysteine = L-cystathionine + H(2)O.
-!- A multifunctional enzyme: catalyzes beta-replacement reaction between L-serine, L-cysteine, cysteine thioethers or some other beta- substituted alpha-L-amino acids and a variety of mercaptans. -!- Formerly EC 4.2.1.21.

UniProtKB Entries (1)

P32582
CBS_YEAST
Saccharomyces cerevisiae S288C
Cystathionine beta-synthase

PDB Structure

PDB 6C2Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.
Tu, Y., Kreinbring, C.A., Hill, M., Liu, C., Petsko, G.A., McCune, C.D., Berkowitz, D.B., Liu, D., Ringe, D.
Biochemistry