CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1360 | Gyrase A; domain 2 |
|
3.30.1360.10 | RNA polymerase, RBP11-like subunit |
Domain Context
CATH Clusters
| Superfamily | RNA polymerase, RBP11-like subunit |
| Functional Family | DNA-directed RNA polymerase subunit alpha |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt P9WGZ1
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
|
UniProtKB Entries (1)
| P9WGZ1 |
RPOA_MYCTU
Mycobacterium tuberculosis H37Rv
DNA-directed RNA polymerase subunit alpha
|
PDB Structure
| PDB | 6C04 |
| External Links | |
| Method | ELECTRON MICROSCOPY |
| Organism | |
| Primary Citation |
Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife
|