CATH Classification

Domain Context

CATH Clusters

Superfamily DnaJ domain
Functional Family

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P17612
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (2)

P00514
KAP0_BOVIN
Bos taurus
CAMP-dependent protein kinase type I-alpha regulatory subunit
P25685
DNJB1_HUMAN
Homo sapiens
DnaJ homolog subfamily B member 1

PDB Structure

PDB 6BYR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of the PKA RI alpha Holoenzyme with the FLHCC Driver J-PKAc alpha or Wild-Type PKAc alpha.
Cao, B., Lu, T.W., Martinez Fiesco, J.A., Tomasini, M., Fan, L., Simon, S.M., Taylor, S.S., Zhang, P.
Structure