CATH Domain 6bv3A04

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.50	Zincin-like fold
	1.25.50.20

Domain Context

CATH Clusters

Superfamily	1.25.50.20
Functional Family	Aminopeptidase N

Enzyme Information

3.4.11.2

Membrane alanyl aminopeptidase.

based on mapping to UniProt P15145

Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

-!- Is not activated by heavy metal ions. -!- Belongs to peptidase family M1. -!- Formerly EC 3.4.1.2, EC 3.4.3.5 and EC 3.4.13.6.

UniProtKB Entries (1)

P15145

AMPN_PIG

Sus scrofa

Aminopeptidase N

PDB Structure

PDB	6BV3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach. Joshi, S., Chen, L., Winter, M.B., Lin, Y.L., Yang, Y., Shapovalova, M., Smith, P.M., Liu, C., Li, F., LeBeau, A.M. Sci Rep