CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family

Enzyme Information

3.4.24.19
Procollagen C-endopeptidase.
based on mapping to UniProt P13497
Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.
-!- The activity is increased by calcium and by an enhancer glycoprotein.

UniProtKB Entries (1)

P13497
BMP1_HUMAN
Homo sapiens
Bone morphogenetic protein 1

PDB Structure

PDB 6BTN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
Kallander, L.S., Washburn, D., Hilfiker, M.A., Eidam, H.S., Lawhorn, B.G., Prendergast, J., Fox, R., Dowdell, S., Manns, S., Hoang, T., Zhao, S., Ye, G., Hammond, M., Holt, D.A., Roethke, T., Hong, X., Reid, R.A., Gampe, R., Zhang, H., Diaz, E., Rendina, A.R., Quinn, A.M., Willette, B.
ACS Med Chem Lett