CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt O60016
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

O60016
CLR4_SCHPO
Schizosaccharomyces pombe 972h-
Histone-lysine N-methyltransferase, H3 lysine-9 specific

PDB Structure

PDB 6BP4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.
Iglesias, N., Currie, M.A., Jih, G., Paulo, J.A., Siuti, N., Kalocsay, M., Gygi, S.P., Moazed, D.
Nature