CATH Domain 6bfaA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

UniProtKB Entries (1)

A0A0F7UUA6_TOXGV

Toxoplasma gondii VEG

CAM kinase, CDPK family TgCDPK1

PDB Structure

PDB	6BFA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. Vidadala, R.S., Rivas, K.L., Ojo, K.K., Hulverson, M.A., Zambriski, J.A., Bruzual, I., Schultz, T.L., Huang, W., Zhang, Z., Scheele, S., DeRocher, A.E., Choi, R., Barrett, L.K., Siddaramaiah, L.K., Hol, W.G., Fan, E., Merritt, E.A., Parsons, M., Freiberg, G., Marsh, K., Kempf, D.J., Carruthers, V.B., Isoherranen, N., Doggett, J.S., Van Voorhis, W.C., Maly, D.J. J. Med. Chem.